3-MeO-PCE Powder

Source

Classification

Chemical Class: Dissociative anesthetic

IUPAC Name: N-ethyl-1-(3-methoxyphenyl)cyclohexanamine hydrochloride

CAS Number: 1797121-52-8

Molecular Formula: C15H23NO·ClH

Synthesis Analysis

Methods

The synthesis of 3-methoxy pce typically involves the reaction of 3-methoxyphenylacetonitrile with ethylamine in the presence of a reducing agent. The process can be adapted for use in forensic laboratories and by chemists involved in the gray market.

Technical Details

The original synthesis described by Geneste et al. has been optimized to allow the production of 3-methoxy pce within a few days using standard laboratory reagents and high-performance liquid chromatography grade solvents. The modified methods include various purification steps to ensure high yields and purity levels suitable for research applications.

Comparative Analysis with Arylcyclohexylamine Derivatives

3-Methoxy-PCE hydrochloride (C₁₅H₂₄ClNO; CAS 1797121-52-8) belongs to the arylcyclohexylamine class, sharing core structural motifs with established dissociative anesthetics while exhibiting distinct substitutions that define its pharmacological profile. Its molecular architecture comprises a cyclohexyl ring bridged to a nitrogen-containing ethylamino group (‑NCH₂CH₃) and a 3-methoxyphenyl aromatic system. This configuration differs critically from several key analogues:

• Phencyclidine (PCP): Features a piperidine ring instead of the ethylamino group. The piperidine nitrogen is incorporated into a heterocyclic structure (‑N< within a six-membered ring), increasing steric bulk and altering receptor engagement kinetics compared to 3-MeO-PCE’s flexible ethyl chain [5].
• Ketamine: Possesses an ortho-chlorinated phenyl ring and a β-keto group adjacent (alpha) to the cyclohexylamine nitrogen. The β-keto moiety significantly influences hydrogen bonding potential and metabolic pathways, absent in 3-MeO-PCE.
• 3-MeO-PCP: Shares the meta-methoxy phenyl substitution but incorporates a piperidine ring analogous to PCP, contrasting with 3-MeO-PCE’s N-ethyl group. This difference impacts lipophilicity and NMDA receptor binding kinetics.

The N-ethyl moiety in 3-MeO-PCE reduces steric hindrance near the nitrogen atom compared to the constrained piperidine in PCP/3-MeO-PCP, potentially enhancing conformational flexibility and receptor interaction dynamics. Simultaneously, the meta-methoxy (‑OCH₃) group on the phenyl ring is a strong electron-donating substituent, influencing the aromatic ring’s electron density and its interaction with hydrophobic receptor pockets. This substitution pattern is a key determinant of its receptor affinity profile among arylcyclohexylamines.

Purity of Perfection: Discover our High-Quality 3-MeO-PCE Powder

As per usual, every batch of our 3-MeO-PCE that gets added to our shelves first undergoes a series of testing by multiple parties to confirm its purity and quality. As a research chemical supplier, we are persistent in maintaining our commitment to quality. As fellow chemical enthusiasts, we settle for nothing less and would never add something to our stock that we would not research ourselves, too. We believe the lab to be a haven. Therefore, we only allow the highest quality research chemicals to make a safe landing on our shelves. We would never offer you less than the best of the best! Enjoy discovering our top-grade 3-MeO-PCE Powder!

Make sure that when you plan on embarking on a scientific journey with this compound that you put aside plenty of time. This substance is potent and its findings are equally as potent. That being said, put aside enough time to thoroughly investigate this compound, as well as time afterward to recover. When you stumble upon so many mind-blowing discoveries, your brain could be tired a day or so after! It can be a lot of data to process and analyse, so make sure time is set aside.

The Important Stuff: What is 3-MeO-PCE?

• Formula Name: N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine
• Case Number: 1364933-80-1
• Formal: C15H23NO
• Formula Weight: 233.355 g·mol−1
• Available Forms: High-quality 3-MeO-PCE Powder.